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Endothelial cell telomere dysfunction induces senescence and results in vascular and metabolic impairments.
Aging Cell. 2023 Aug;22(8):e13875. doi: 10.1111/acel.13875. Epub 2023 May 31.
Aging Cell. 2023.
PMID: 37259606
Free PMC article.
Reduction of double-strand DNA break repair exacerbates vascular aging.
Bloom SI, Tucker JR, Machin DR, Abdeahad H, Adeyemo AO, Thomas TG, Bramwell RC, Lesniewski LA, Donato AJ.
Bloom SI, et al. Among authors: thomas tg.
Aging (Albany NY). 2023 Oct 2;15(19):9913-9947. doi: 10.18632/aging.205066. Epub 2023 Oct 2.
Aging (Albany NY). 2023.
PMID: 37787989
Free PMC article.
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Aging results in DNA damage and telomere dysfunction that is greater in endothelial versus vascular smooth muscle cells and is exacerbated in atheroprone regions.
Bloom SI, Tucker JR, Lim J, Thomas TG, Stoddard GJ, Lesniewski LA, Donato AJ.
Bloom SI, et al. Among authors: thomas tg.
Geroscience. 2022 Dec;44(6):2741-2755. doi: 10.1007/s11357-022-00681-6. Epub 2022 Nov 9.
Geroscience. 2022.
PMID: 36350415
Free PMC article.
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